32nd Annual Student Research Conference
Investigating Isoflavone Derivatives as a Treatment for Endometriosis
Allison B. Esselman
Dr. Bill R. Miller, Faculty Mentor
Endometriosis is a disease that affects 1 out of every 10 women, or about 176 million women, worldwide. This disease causes the lining of the uterine wall, the endometrium, to grow outside of the uterus causing intense pain and other harmful symptoms. Currently, there are drugs on the market to treat endometriosis; however, these drugs come with their own unpleasant side effects. One of the main contributors to this disease is the protein aromatase. Aromatase is key in the biosynthesis of estradiol, which causes the endometrium to grow. Isoflavones are a natural product recently suggested to be a treatment for endometriosis without the harsh side effects. The goal of this computational biochemical research is to find a novel isoflavone derivative that completely inhibits aromatase better than previously reported compounds.
Keywords: Endometriosis, Aromatase, Isoflavone, Computational
Topic(s):Chemistry
Biochemistry and Molecular Biology
Presentation Type: Oral Paper
Session: 211-5
Location: MC 212
Time: 11:15