2017 Student Research Conference:
30th Annual Student Research Conference

Using RNAseq Data to Explore the Biological Networks of Autism Spectrum Disorder

Jessica L. Kottmeier
Dr. Ashley Ramsey, Faculty Mentor

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impairs social and occupational abilities. ASD prevalence is growing but little remains known about the causes or the biological pathways implicated. Many genes have been identified in RNAseq studies that are differentially expressed in ASD that gives insight into potential biological processes. TSHZ3, a transcription factor associated with layer specific cortical projection neurons, has been identified as a hub gene in ASD. Alpha-T catenin has also been shown to be involved in Autism. This study investigates the differentially expressed genes in TSHZ3 knockout mice and alpha-T catenin knockout mice to elucidate their roles in biological networks and mechanisms that contribute to Autism Spectrum Disorder. Results of these data will be discussed.

Keywords: Autism, RNAseq, TSHZ3, Alpha-T catenin


Presentation Type: Poster

Session: 6-
Location: GEO - SUB

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