30th Annual Student Research Conference
Determining the Role of tbcd-1 in Caenorhabditis elegans Embryonic Development
Dakota A. Hall
Dr. Stephanie Maiden, Faculty Mentor
Microtubules and microtubule-associated proteins (MAPs) are known to play a role in providing structure and motility to cells and their contents. By observing the effects of feeding RNAi on genes than encode for MAPs, information elucidating the role they play during epithelial morphogenesis can be acquired. The gene that encodes Tubulin-Specific Chaperone D, tbcd-1, is important in the tubulin folding pathway, making it an intuitive target for studying microtubule dynamics in epithelia. Wild-type worms with RNAi knockdown of tbcd-1 exhibit embryonic lethality with epithelial defects. This information can assist in an overall understanding of a novel role that tbcd-1 plays in microtubule dynamics within the developing epithelium, providing precedence to continue more specialized experimental investigation into the gene.
Keywords: Microtubules, Reverse Genetics, Developmental Biology
Topic(s):Biology
Presentation Type: Poster
Session: 6-
Location: GEO - SUB
Time: