CRLF3 Expression in Rat Brains

Rachel N. Rushman
Dr. Daniela Ostrowski (A.T. Still University) and Dr. Brett A. Berke, Faculty Mentors

While primarily controlling red blood cells (RBC) production, erythropoietin (Epo) has neuroprotective effects. While the classical Epo receptor (EPOR) mediates RBC production, the receptor for neuroprotection is not known. In insects, the cytokine receptor-like factor 3 (CRLF3) is proposed for Epo’s neuroprotective effects. Our lab started characterizing the expression and function of CRLF3 in rats. My project utilizes immunochemistry to describe the expression of CRLF3 in rat brains. Using cell-specific markers, I will analyze the colocalization of CRLF3 with neurons, astrocytes and microglia in forebrain, midbrain, brainstem, and spinal cord sections. I hypothesize that CRLF3 colocalizes with neurons due to its proposed function in Epo-mediated neuroprotection.

Keywords: neuroprotection, erythropoietin, brains, immunochemistry, rats, colocalization

Topic(s):Biology
Biochemistry and Molecular Biology

Presentation Type: Poster Presentation

Session: TBA
Location: TBA
Time: TBA