2024 Student Research Conference:
37th Annual Student Research Conference

Oxidation of 5-Methylisatin for the Synthesis of a Potential Anticancer Drug

Alison R. Regina
Dr. Justine R. Olson, Faculty Mentor

DN29 is an anticancer drug computationally discovered by Dr. Bill Miller’s group at Truman State University. DN29 targets the APOBEC3B protein which is often overexpressed in metastases, late-stage, and hard-to-treat cancers. This drug could be easily synthesized in three steps: a friedel-crafts-like addition, an oxidation, and a cyclization. All three steps use low-cost and commonly used chemicals widely available in the pharmaceutical industry. The oxidation step has proven especially difficult to optimize. Several oxidizers have been tested including copper and oxygen, ceric ammonium nitrate, and lemon juice. 

Keywords: Chemistry, Cancer, Drug, Synthesis, Oxidation, Organic, Anticancer , Lab


Presentation Type: Oral Presentation

Session: 206-4
Location: MG 2001
Time: 11:15

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