2022 Student Research Conference:
35th Annual Student Research Conference

Using Analytical Methods to Determine Polyphenol Effect on Aβ Aggregation


Adam D. Vaske* and Ella Mozier
Dr. Brittany Hagenhoff , Faculty Mentor

Alzheimer’s disease (AD), a crippling neurological disorder affecting one in nine people, age 65 and older, involves the formation of plaques composed of the amyloid-beta (Aβ) protein. Although no standard treatment has been developed for AD, numerous studies have focused on the potential treatment utilizing polyphenolic compounds. Polyphenolic compounds are naturally occurring antioxidants that are found in many foods we consume. The polyphenols resveratrol, piceatannol, diethylstilbestrol, and pterostilbene were studied to monitor their effects on the aggregation of the Aβ 1 - 42 protein. Analysis of the polyphenols as well as the untreated protein was performed using the Thioflavin T (ThT) fluorescence assay and effects have been observed.

Keywords: Amyloid Beta, Alzheimer's, Analytical Chemistry, Biochemistry, Polyphenol , UV-Vis, Fluorometry , Protein

Topic(s):Biochemistry and Molecular Biology
Chemistry
Biology

Presentation Type: Oral Presentation

Session: 305-3
Location: MG 2001
Time: 1:45

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