2018 Student Research Conference:
31st Annual Student Research Conference

Examining the Role of cls-2 in the Developing Epidermis of Caenorhabditis elegans

Angela K. Jennings
Dr. Stephanie Maiden, Faculty Mentor

Microtubules have been shown to be essential in the development in the epidermis of C. elegans. The specific proteins involved in their development are not well understood. The gene cls-2 is suspected to be involved in the stabilization and formation of microtubules. Using a feeding RNAi approach, cls-2 has demonstrated success in producing novel phenotypes in C. elegans. However embryonic death occurred before epidermal morphogenesis began indicating the microtubules affected were involved in cellular division. Future experimentation will examine the effect of cls-2 knockdown on development of the epidermis of C. elegans using RNAi by injection in worm strains that will only allow knockdown in the epidermis. Immunofluorescence microscopy will then be used to understand the mechanism for any microtubule effects.

Keywords: microtubule, cls-2, Caenorhabditis elegans, RNAi, epidermis


Presentation Type: Poster

Session: 3-7
Location: GEO - SUB
Time: 3:30

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