2018 Student Research Conference:
31st Annual Student Research Conference

Virtual Screening of Potential Inhibitors of APOBEC3B: a Promising Cancer Drug Target

Zachary D. Smith
Dr. Bill R. Miller, Faculty Mentor

APOBEC3B is a protein implicated in many cancers such as breast, liver, and colon. This protein is a DNA cytosine deaminase and converts cytosine, a DNA base, to uridine, an RNA base. This causes increased mutations in the DNA and makes cancers harder to treat. Finding a potential molecule to stop this process and inhibit the function of APOBEC3B can assist doctors in treating cancers more accurately. Using computer modeling, the protein can be analyzed at the atomic level for interactions with potential inhibitory molecules. This analysis is useful for drug development to decrease the number of potential inhibitors to test and can assist researchers in developing anti-cancer drugs. The project has found several potential inhibitors of APOBEC3B. These potential inhibitors have been analyzed and ranked based on their binding affinity to the protein.  

Keywords: Cancer, Biochemistry, Computational Modeling


Presentation Type: Oral Paper

Session: 103-2
Location: MG 1096
Time: 8:15

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