22nd Annual Student Research Conference
Solution Dynamics of Lead(II) Complexes of Relevance to Protein Active Sites
Margaret A. Mudd
Dr. James McCormick, Faculty Mentor
Lead poisoning continues to be an issue in the United States despite stringent governmental regulations placed on leads use. The chelating agents used to treat lead poisoning lack specificity and have several detrimental side effects. To assist in the development of lead-specific chelating agents, this project will investigate the coordination chemistry of lead(II) in solution. The solution structure and dynamics of the Pb2+ complexes of tris[(2-pyridyl)methyl]amine (TPA) are studied using NMR spectroscopic methods. The 1H and 13C NMR spectra are interpreted as indicating that the structures of the [Pb(TPA)](NO3)2, [Pb(TPA)2](ClO4)2, and [Pb(TPA)2](PF6)2(DMF)2 complexes in solution depend on concentration and solvent. There is no evidence that the complexes dissociate under the experimental conditions. The observed broadening of the signals in the 1H NMR of [Pb(TPA)]2+ at lower concentrations indicates that there is some level of ion pairing in solution.
Keywords: Lead
Topic(s):Chemistry
Presentation Type: Poster
Session: 11-6
Location: PML
Time: 4:15