39th Annual Student Research Conference
LOX-1 Engagement by oxLDL Modulates Alveolar Macrophage Response During Pneumonia
Aubrey N. Watkins
Dr. Filiz Korkmaz (University of Iowa) and Dr. Joyce Patrick, Faculty Mentors
Pneumonia inflames the alveoli of the lungs, impairing gas exchange and oxygenation of the blood. It is the leading cause of infectious disease-related deaths worldwide and is driven by a wide range of pathogens. Treatment is limited to antibiotics and supportive care, highlighting the need for therapies targeting the host immune response. Alveolar macrophages (AMs), the lung’s resident immune cells, play a dual role: clearing pathogens and limiting inflammation to protect tissues. Recent studies suggest LOX-1, a scavenger receptor on AMs, may enhance immunomodulatory functions. This study investigates how LOX-1 activation by oxidized low-density lipoprotein (oxLDL) affects AM phenotype and cytokine production during inflammation. AMs were treated with oxLDL, with or without a LOX-1 neutralizing antibody. Activity was assessed by cytokine production, gene expression, and M1/M2-like markers. Preliminary findings suggest oxLDL pretreatment may reduce pro-inflammatory cytokines, while LOX-1 signaling may play a nuanced role in inflammatory and homeostatic processes.
Keywords: pneumonia, alveolar macrophages, inflammation, LOX-1, oxLDL
Topic(s):Biology
Presentation Type: Poster Presentation
Session: -22
Location: Activities Room
Time: 2:30