37th Annual Student Research Conference
Deconvoluting Moment of Inertia Contributions in Isotopic Shifts with High-Resolution Cyclic Ion Mobility Separations
Haisley M. Windsor
Dr. James McCormick, Faculty Mentor
Ion mobility spectrometry-mass spectrometry (IMS-MS) is an analytical technique, where ions separate based on their size, shape, and charge. Despite technological advancements, theory does not account for all experimental observations such as mass distribution-based shifts stemming from center of mass and moment of inertia (MOI) contributions.Thus, this calls for new experiments that can better understand isotopic shifts related to mass distribution. Tetrapropyl ammonium salt isotopologues were chosen due to their symmetrical structure and fixed charge, allowing variation only in MOI. The isotopologues were synthesized from deuterium labeled bromopropane and separated in a cyclic IMS-MS platform. Differences in MOI led to varying arrival times and thus structural differences (CCS values). A relationship between MOI and CCS was established and found to be linear. Overall, this represents the first demonstration of isolating MOI contributions in experimentally-measured isotopic shifts and helps improve our understanding of ion structure.
Keywords:
Topic(s):Chemistry
Presentation Type: Oral Presentation
Session: 106-1
Location: MG 2001
Time: 9:15