2014 Student Research Conference:
27th Annual Student Research Conference

The Effect of Phosphatidylserine on Learning and Memory Task Performance in Rodents: A Meta-Analysis
Grace O. Robinson* and Joseph R. Gregory
Dr. Jeffrey Vittengl, Faculty Mentor

The endogenous phospholipid phosphatidylserine (PS) may affect learning and memory. This meta-analysis examines the performance of PS-treated versus control mice and rats on learning and memory tasks and moderation of PS effects by source (bovine cortex [BC-PS] or soybean-derived [SB-PS]), starting condition of the animals (aged, cholinergically impaired, or unimpaired), and type of task (active avoidance, passive avoidance, or Morris water maze). PS improved mean performance compared to control (d = 0.93, SE = 0.09, p < .001), with a larger effect for BC-PS (d = 1.13) than SB-PS (d = 0.49) and a larger effect for impaired (d = 0.81) and aged (d = 1.18) than unimpaired (d = 0.72) rodents. No significant differences were found among the different tasks. These results support future research with SB-PS in a human population as a potential treatment for age-related cognitive impairment as well as an enhancer of normal cognitive function.

Keywords: phosphatidylserine, cognitive impairment, learning, memory, meta-analysis


Presentation Type: Oral Paper

Session: 310-4
Location: MG 2001
Time: 1:45

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