24th Annual Student Research Conference
Characterization of Single Nucleotide Polymorphisms in the SLITRK1 Gene of Individuals Exhibiting Tourette's Syndrome
Lauren A. Choate
Dr. Brent Buckner, Faculty Mentor
Tourette's Syndrome (TS) is a neuropsychiatric disorder characterized by vocal or motor tics. The Slit and Trk-like family member 1 (SLITRK1) gene is thought to contribute to the TS phenotype. SLITRK1 encodes a transmembrane protein that is thought to be involved in neurite outgrowth. The intent of this study was to characterize if either of two single nucleotide polymorphisms (SNP) in the SLITRK1 gene are associated with TS in a family segregating for two affected individuals. DNA was isolated, amplified by PCR, cloned into recombinant plasmid, and sequenced from two regions in the SLITRK1 gene for each individual. No evidence for the presence of either of these SNPs was identified in this family. However, further studies would be required to definitively rule out these SNPs as being present in the affected family members. This study was performed as part of the laboratory experience in Biol 551 "Genetics of Human Disorders".
Keywords: Tourette's, SLITRK1 Gene, Single Nucleotide Polymorphism
Topic(s):Biology
Presentation Type: Poster
Session: 3-9
Location: Georgian Room - SUB
Time: 4:30