19th Annual Student Research Conference
Science
Chronic NF-κB Inhibition Increased Fiber Number in the Aging Triangularis Sterni (TS) of Mdx Mice
Ashley L. Siegel♦
Dr. C. George Carlson (AT Still University) and Dr. John J. Rutter, Faculty Mentors
Duchenne muscular dystrophy is a lethal disorder caused by a deletion in the cytoskeletal protein dystrophin. The murine model of this disease (mdx) was chronically injected with PDTC, an NF-κB inhibitor. PDTC treatment increased the number of fibers, decreased the percent centronucleation, and altered the distribution and mean of fiber diameter. The TS muscle has regional differences of activation due to differential orientation of fibers to the sternum and costal cartilage (De Troyer et al., J. Physiol (Lond), 513.3, 915, 1998). In terms of total fiber number, the cephalad region was most profoundly affected by the disease (p=0.004). PDTC treatment increased the number of fibers in both the cephalad (p=0.025) and caudal (p=0.022) regions but not in the middle region of the TS. These results indicate that NF-κB is pathogenic in Duchenne muscular dystrophy.
Keywords: mdx , NF-κB , triangularis sterni, dystrophy, muscle
Topic(s):Biology
Presentation Type: Oral Paper
Session: 27-4
Location: VH 1408
Time: 10:30