DNA Methylation and Gene Expression Microarray Analysis of Mantle Cell Lymphoma Tumors
John A. Brockman
Dr. David Klinkebiel (University of Nebraska Medical Center) and Dr. Anton E. Weisstein, Faculty Mentors
Mantle Cell lymphoma is caused by malignant B lymphocytes which are found in the mantle zone. A change in DNA methylation can result in repression of genes that control cell growth, repair DNA damage, apoptosis, and/or reexpression of normally silenced gene. The goal of this study is to determine methylation patterns of mantle cell lymphoma tumors and how these patterns influence gene expression and cancer development. Ultimately, these studies could lead to the identification of prognostic markers for patients with the disease. Although a more extensive analysis of changes in methylation and gene expression in mantle cell lymphoma tumors is only beginning, we can conclude that there are a number of signaling proteins and transcriptional regulatory factors whose expression could be regulated by DNA methylation. This process in turn, could lead to changes in expression of other genes that are not directly affected by methylation changes in nearby CpG islands.
Keywords: DNA methylation, microarray, lymphoma, CpG Island
Presentation Type: Poster
Location: OP Lobby and Atrium