2021 Student Research Conference:
34th Annual Student Research Conference

Alzheimer’s Prevention Using the Antioxidative Power of Polyphenolic Compounds


Kayla Wheelehan
Dr. Brittany Hagenhoff, Faculty Mentor

Kayla N. Wheelehan

Dr. Brittany Hagenhoff, Faculty Mentor


 

    Alzheimer's disease is the leading cause of dementia, accounting for 60-80% of all dementia cases. This disease causes progressive memory loss and loss of cognitive function for those who suffer from it. While much is still unknown, a certain characteristic of the disease is aggregation of the protein Amyloid-beta (A-beta). Determining preventative measures for the aggregation of the amyloid plaques is vital to stopping the progression of this disease. Polyphenolic compounds such as Piceatannol, Resveratrol, Pterostilbene, and Diethylstilbestrol, all structurally similar, provide antioxidative properties that may be able to prevent this aggregation. This study focuses on these polyphenols' ability to prevent the aggregation of Abeta utilizing a fluorescence-based assay. Results have shown that there is a trend between the structure of the polyphenols, specifically the number of hydroxyl substituents, and their ability to prevent aggregation of A-beta. 

 

Keywords: Alzheimers, Chemistry

Topic(s):Chemistry

Presentation Type: Asynchronous Virtual Oral Presentation

Session: 6-11
Location: https://flipgrid.com/ebc10430
Time: 0:00

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