2019 Student Research Conference:
32nd Annual Student Research Conference

Investigating Isoflavone Derivatives as a Treatment for Endometriosis


Allison B. Esselman
Dr. Bill Miller, Faculty Mentor

Endometriosis is a disease that affects 1 out of every 10 women, or about 176 million women, worldwide.  This disease causes the lining of the uterine wall, the endometrium, to grow outside of the uterus causing intense pain and other harmful symptoms.  Currently, there are drugs on the market to treat endometriosis; however, these drugs come with their own unpleasant side effects.  One of the main contributors to this disease is the protein aromatase.  Aromatase is key in the biosynthesis of estradiol, which causes the endometrium to grow.  Isoflavones are a natural product recently suggested to be a treatment for endometriosis without the harsh side effects.  The goal of this computational biochemical research is to find a novel isoflavone derivative that completely inhibits aromatase better than previously reported compounds.         

Keywords: Endometriosis, Aromatase, Isoflavone, Computational

Topic(s):Chemistry
Biochemistry and Molecular Biology

Presentation Type: Oral Paper

Session: 211-5
Location: MC 212
Time: 11:15

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